Primovir Combipack (Nirmatrelvir 150mg + Ritonavir 100mg)

PAXLOVID (Paxzen) Overview

PAXLOVID (Paxzen) is an investigational medicine authorized for emergency use by the FDA to treat mild-to-moderate COVID-19 in adults and pediatric patients (12 years of age and older weighing at least 40 kg) with positive results from direct SARS-CoV-2 viral testing. It is specifically intended for individuals at high risk of progressing to severe COVID-19, including hospitalization or death.

About COVID-19

COVID-19 is caused by the coronavirus, which can spread through close contact with infected individuals. While many cases are mild, some can be severe and lead to complications, especially in individuals with underlying health conditions such as heart disease, lung disease, and diabetes.

About PAXLOVID (Paxzen)

PAXLOVID is still being studied and is considered investigational, meaning there is limited information about its safety and effectiveness. It consists of two components: nirmatrelvir and ritonavir.

• Nirmatrelvir: This component inhibits the main protease enzyme of SARS-CoV-2, which is essential for the virus to replicate within human cells.
• Ritonavir: Used to increase the blood levels of nirmatrelvir by inhibiting its breakdown in the body.

Who Can Take PAXLOVID?

PAXLOVID is authorized for emergency use in the following groups:

• Age: Adults and pediatric patients aged 12 years and older weighing at least 40 kg.
• COVID-19 Positive: Individuals must have a positive test for the SARS-CoV-2 virus.
• High Risk: Patients at high risk of severe COVID-19, including those likely to require hospitalization or face fatal outcomes.

High-Risk Criteria for Severe COVID-19

People with the following conditions are considered at high risk for severe COVID-19:

• Age 65 years or older
• Cancer
• Chronic kidney disease
• Chronic liver disease
• Chronic lung disease (e.g., COPD, asthma)
• Diabetes (Type 1 or Type 2)
• Heart conditions
• Immunocompromised state or weakened immune system
• Obesity
• Pregnancy or recent pregnancy
• Sickle cell disease or thalassemia
• Smoking history
• Solid organ or blood stem cell transplant

Side Effects of PAXLOVID

Common side effects of PAXLOVID may include changes in taste, diarrhea, high blood pressure, or muscle pain. It’s important to notify your healthcare provider promptly if these symptoms persist or worsen.

Serious side effects that require immediate medical attention include signs of liver problems (such as persistent nausea, vomiting, abdominal pain, yellowing of eyes/skin, dark urine) and allergic reactions (e.g., rash, swelling of face/tongue/throat, severe dizziness, difficulty breathing).

Conclusion

PAXLOVID offers a potential treatment option for individuals with mild-to-moderate COVID-19 who are at high risk for severe illness. As an investigational medicine under emergency use authorization, its use should be guided by healthcare providers based on individual risk factors and medical history. Regular monitoring for side effects and consultation with healthcare professionals are crucial during treatment with PAXLOVID.